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SPRB

Spruce Biosciences, Inc. (NASDAQ)

Healthcare — Biotechnology

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, including anhedonia, weight alterations, and altered sleeping patterns. In addition, the company develops SPR202 for the treatment of Congenital Adrenal Hyperplasia (CAH), a chronic and potentially life-threatening rare disease with no cure. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize various pharmaceutical compounds. It also has a collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize Tildacerfont for the treatment of CAH in Japan. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in South San Francisco, California.

Strong Buy 1.1 / 5 7 analysts
$52.81
+$0.27 (+0.50%)
Target: $149.71 (183.5%)
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Price History

52-Week Range

Fundamentals

Market Cap$145.35M
P/E Ratio (TTM)-
Forward P/E10.67
EPS (TTM)$-35.82
Dividend Yield-
Profit Margin-
Revenue Growth-
ROE-148.85%
Debt/Equity20.56
Recommendation Strong Buy 1.1
Analyst Target$149.71
Analysts7
Indexes NASDAQ

Technical Indicators

RSI (14)57.2
Beta3.20
SMA 20-
SMA 40-
52-Week High$838.13
52-Week Low$7.00
50-Day Avg$53.01
200-Day Avg$73.45
Avg Volume77.3K
Volume542

Performance Analysis

BULLISH

SPRB shows predominantly bullish signals based on its fundamentals and technicals.

+ Trading near its 52-week low ($7.00), which could present a value opportunity.
+ RSI at 57.2 shows positive momentum.
- Price is below both the 50-day and 200-day moving averages — in a downtrend.
+ Wall Street consensus is "Strong Buy" from 7 analysts.
+ Average analyst target of $149.71 implies 183.5% upside.

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Last updated: Jul 02, 2026 13:32 UTC

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